[Answered]: A 34-year-old man comes to the ofice due to…

A 34-year-old man comes to the ofice due to shortness of breath. He reports an episodic cough and chest tightness for the past 4 months. Thepatent was recenty on a 2-week vacalon in Azona and reports that he had no symptoms duning the tip butthat thev restared when he relumechome. He has no prior medical conditions and takes no medicalions. The palient smoked marjuana in his early 20s for several years but doesnot use tobacco or alcohol. He started working at a chemical manufacturing factory 7 months ago and has had no sick contacts. Temperature is36.7 C(98 F), blood pressure is 120/80 mm Hg, pulse is 76/min, and respirations are 18/min. On physical examination, expiration is mildyprolonged and there are scaltered wheezes. Ofice spirometry shows an FEV1/FVC of 829%, and chest radiography reveals no abnormalitiesWhich of the following features is most likely involved in the pathogenesis of this patient’s condition?